Treatment for dry skin conditions. E45 cream has been clinically proven to treat and soothe dry, itching, flaking, chapped, rough and calloused skin, sunburn and detergent hands. It's non-greasy emollient formulation leaves your skin soft, comfortable and relieved. E45 Cream is also for more serious dry skin conditions such as eczema, dermatitis, ichtyhosis and certain dry cases of psoriasis. Perfume Free - dermatologically tested.